Expression of the mannose receptor CD206 in HIV and SIV encephalitis: a phenotypic switch of brain perivascular macrophages with virus infection.
Title | Expression of the mannose receptor CD206 in HIV and SIV encephalitis: a phenotypic switch of brain perivascular macrophages with virus infection. |
Publication Type | Journal Article |
Year of Publication | 2014 |
Authors | Holder, GE, McGary, CM, Johnson, EM, Zheng, R, John, VT, Sugimoto, C, Kuroda, MJ, Kim, W-K |
Journal | J Neuroimmune Pharmacol |
Volume | 9 |
Issue | 5 |
Pagination | 716-26 |
Date Published | 2014 Dec |
ISSN | 1557-1904 |
Keywords | Animals, Encephalitis, External, Gene Expression Regulation, Viral, HIV Infections, HIV-1, Humans, Lectins, C-Type, Macaca mulatta, Macrophages, Male, Mannose-Binding Lectins, Phenotype, Receptors, Cell Surface, Simian Acquired Immunodeficiency Syndrome, Simian immunodeficiency virus |
Abstract | We examined the expression of the mannose receptor CD206 by perivascular macrophages (PVM) in normal human and monkey brains and in brains of HIV-infected humans and of monkeys infected with simian immunodeficiency virus (SIV). Depletion of brain PVM in SIV-infected monkeys by intrathecal injection of liposome-encapsulated bisphosphonates eliminated CD206-expressing cells in the brain, confirming their perivascular location and phagocytic capacity. In vivo labeling with bromodeoxyuridine in normal uninfected and SIV-infected macaques in combination with CD206 immunostaining revealed a CD206+-to-CD206- shift within pre-existing PVM during SIV brain infection and neuroinflammation. These findings identify CD206 as a unique marker of human and macaque PVM, and underscore the utility of this marker in studying the origin, turnover and functions of these cells in AIDS. |
DOI | 10.1007/s11481-014-9564-y |
Alternate Journal | J Neuroimmune Pharmacol |
PubMed ID | 25146376 |
PubMed Central ID | PMC4364002 |
Grant List | R01 AI097059 / AI / NIAID NIH HHS / United States R01AI097059 / AI / NIAID NIH HHS / United States R21 AI091501 / AI / NIAID NIH HHS / United States R21 AI110163 / AI / NIAID NIH HHS / United States R21AI091501 / AI / NIAID NIH HHS / United States R21AI110163 / AI / NIAID NIH HHS / United States R24 MH059724 / MH / NIMH NIH HHS / United States R24MH59724 / MH / NIMH NIH HHS / United States |