Dynamics of monocyte chemoattractant protein type one (MCP-1) and HIV viral load in human cerebrospinal fluid and plasma
Submitted by dcc on Wed, 04/23/2014 - 7:47am
Title | Dynamics of monocyte chemoattractant protein type one (MCP-1) and HIV viral load in human cerebrospinal fluid and plasma |
Publication Type | Journal Article |
Year of Publication | 2005 |
Authors | Monteiro de Almeida, S, Letendre, S, Zimmerman, J, Lazzaretto, D, McCutchan, JA, Ellis, RJ |
Journal | Journal of Neuroimmunology |
Volume | 169 |
Issue | 1-2 |
Pagination | 144-52 |
Date Published | 12/2005 |
Keywords | Internal, RNA, Viral |
Abstract | BACKGROUND: Increased expression of monocyte chemoattractant protein type 1 (MCP-1) is associated with HIV CNS disease. This study evaluated the temporal relationships between MCP-1 expression and HIV replication in the CNS. METHODS: MCP-1 and HIV viral load (VL) were measured in serially obtained samples of plasma and cerebrospinal fluid (CSF) in subjects either interrupting (TI) or starting (TS) antiretroviral therapy. RESULTS: Following TI, plasma VL rebounded first, followed by increases in CSF MCP-1, which immediately preceded or coincided with a rebound of CSF VL. CONCLUSION: The close temporal relationship of the increase of MCP-1 and CSF VL suggests that they are co-regulated, or that one is a stimulus for the other. |
URL | http://www.ncbi.nlm.nih.gov/pubmed/16182380 |