At-Risk Alcohol Use is Associated with Antiretroviral Treatment Nonadherence Among Adults Living with HIV/AIDS.
Title | At-Risk Alcohol Use is Associated with Antiretroviral Treatment Nonadherence Among Adults Living with HIV/AIDS. |
Publication Type | Journal Article |
Year of Publication | 2017 |
Authors | Paolillo, EW, Gongvatana, A, Umlauf, A, Letendre, SL, Moore, DJ |
Journal | Alcohol Clin Exp Res |
Volume | 41 |
Issue | 8 |
Pagination | 1518-1525 |
Date Published | 2017 Aug |
ISSN | 1530-0277 |
Keywords | Adult, Aged, Alcohol Drinking, Alcoholism, Anti-Retroviral Agents, Cohort Studies, Female, HIV Infections, Humans, Internal, Male, Medication Adherence, Middle Aged, Treatment Outcome, Young Adult |
Abstract | BACKGROUND: Alcohol use is a risk factor for nonadherence to antiretroviral therapy (ART) among people living with HIV/AIDS (PLWHA); however, differences in ART adherence across levels of alcohol use are unclear. This study examined whether "at-risk" alcohol use, defined by National Institute of Alcohol Abuse and Alcoholism guidelines, was associated with ART nonadherence among PLWHA.METHODS: Participants were 535 HIV-infected adults enrolled in studies at the HIV Neurobehavioral Research Program. ART nonadherence was identified by either self-reported missed dose or plasma viral load detectability (≥50 copies/ml). Potential covariates for multivariable logistic regression included demographics, depression, and substance use disorders.RESULTS: Using a stepwise model selection procedure, we found that at-risk alcohol use (OR = 0.64; p = 0.032) and low education (OR = 1.09 per 1 year increase in education; p = 0.009) significantly predict lower ART adherence.CONCLUSIONS: A greater focus on the treatment of at-risk alcohol use may improve ART adherence among HIV-infected persons. |
DOI | 10.1111/acer.13433 |
Alternate Journal | Alcohol Clin Exp Res |
PubMed ID | 28679147 |
PubMed Central ID | PMC5564671 |
Grant List | P50 DA026306 / DA / NIDA NIH HHS / United States HHSN271201000030C / MH / NIMH NIH HHS / United States U24 MH100928 / MH / NIMH NIH HHS / United States HHSN271201000036C / MH / NIMH NIH HHS / United States R24 MH059745 / MH / NIMH NIH HHS / United States T32 DA031098 / DA / NIDA NIH HHS / United States T32 AA013525 / AA / NIAAA NIH HHS / United States P30 MH062512 / MH / NIMH NIH HHS / United States P01 DA012065 / DA / NIDA NIH HHS / United States U01 MH083506 / MH / NIMH NIH HHS / United States N01 MH022005 / MH / NIMH NIH HHS / United States |