Effects of traumatic brain injury on cognitive functioning and cerebral metabolites in HIV-infected individuals.
Title | Effects of traumatic brain injury on cognitive functioning and cerebral metabolites in HIV-infected individuals. |
Publication Type | Journal Article |
Year of Publication | 2011 |
Authors | Lin, K, Taylor, MJ, Heaton, R, Franklin, D, Jernigan, T, Fennema-Notestine, C, McCutchan, A, J Atkinson, H, Ellis, RJ, McArthur, J, Morgello, S, Simpson, D, Collier, AC, Marra, C, Gelman, B, Clifford, D, Grant, I |
Corporate Authors | CHARTER Group |
Journal | J Clin Exp Neuropsychol |
Volume | 33 |
Issue | 3 |
Pagination | 326-34 |
Date Published | 2011 Mar |
ISSN | 1744-411X |
Keywords | Adult, Aspartic Acid, Brain Injuries, Cognition Disorders, Depression, Executive function, Female, HIV Infections, Humans, Magnetic Resonance Spectroscopy, Male, Memory, Short-Term, Middle Aged, Neuropsychological Tests, Psychiatric Status Rating Scales, Substance-Related Disorders |
Abstract | We explored the possible augmenting effect of traumatic brain injury (TBI) history on HIV (human immunodeficiency virus) associated neurocognitive complications. HIV-infected participants with self-reported history of definite TBI were compared to HIV patients without TBI history. Groups were equated for relevant demographic and HIV-associated characteristics. The TBI group evidenced significantly greater deficits in executive functioning and working memory. N-acetylaspartate, a putative marker of neuronal integrity, was significantly lower in the frontal gray matter and basal ganglia brain regions of the TBI group. Together, these results suggest an additional brain impact of TBI over that from HIV alone. One clinical implication is that HIV patients with TBI history may need to be monitored more closely for increased risk of HIV-associated neurocognitive disorder signs or symptoms. |
DOI | 10.1080/13803395.2010.518140 |
Alternate Journal | J Clin Exp Neuropsychol |
PubMed ID | 21229435 |
PubMed Central ID | PMC3062232 |
Grant List | N01 MH022005 / MH / NIMH NIH HHS / United States |