COMT Val158Met Polymorphism, Cardiometabolic Risk, and Nadir CD4 Synergistically Increase Risk of Neurocognitive Impairment in Men Living With HIV
Submitted by dcc on Mon, 01/27/2020 - 5:19pm
Title | COMT Val158Met Polymorphism, Cardiometabolic Risk, and Nadir CD4 Synergistically Increase Risk of Neurocognitive Impairment in Men Living With HIV |
Publication Type | Journal Article |
Year of Publication | 2019 |
Authors | Saloner, R, Marquine, MJ, Sundermann, EE, Hong, S, McCutchan, JA, Ellis, RJ, Heaton, RK, Grant, I, Cherner, M |
Journal | Journal of Acquired Immune Deficiency Syndromes |
Volume | 81 |
Start Page | 148 |
Date Published | 08/2019 |
Keywords | Internal |
Abstract | The Val allele of the Val158Met single-nucleotide polymorphism of the catechol-o-methyltransferase gene (COMT) results in faster metabolism and reduced bioavailability of dopamine (DA). Among persons living with HIV, Val carriers |