HIV Stroke Risk: Evidence and Implications
Title | HIV Stroke Risk: Evidence and Implications |
Publication Type | Journal Article |
Year of Publication | 2013 |
Authors | Singer, EJ, Valdes-Sueiras, M, Commins, D, Yong, WH, Carlson, M |
Journal | Therapeutic Advances in Chronic Disease |
Volume | 4 |
Issue | 2 |
Pagination | 61-70 |
Date Published | 03/2014 |
Keywords | Atherosclerosis, cerebrovascular, human immunodeficiency virus type 1, Infection, Inflammation, Internal, stroke |
Abstract | An estimated 34 million men, women, and children are infected with human immunodeficiency virus type 1 (HIV-1), the virus that causes acquired immunodeficiency syndrome (AIDS). Current technology cannot eradicate HIV-1, and most patients with HIV-1-infection (HIV+) will require lifelong treatment with combined antiretroviral therapy (cART). Stroke was recognized as a complication of HIV-1 infection since the early days of the epidemic. Potential causes of stroke in HIV-1 include opportunistic infections, tumors, atherosclerosis, diabetes, hypertension, autoimmunity, coagulopathies, cardiovascular disease, and direct HIV-1 infection of the arterial wall. Ischemic stroke has emerged as a particularly significant neurological complication of HIV-1 and its treatment due to the aging of the HIV+ population, chronic HIV-1 infection, inflammation, and prolonged exposure to cART. New prevention and treatment strategies tailored to the needs of the HIV+ population are needed to address this issue. |
URL | http://www.ncbi.nlm.nih.gov/pubmed/?term=23556125 |
DOI | 10.1177/2040622312471840 |