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Polyomaviruses and primary central nervous system lymphomas

Submitted by dcc on Wed, 04/23/2014 - 7:47am
TitlePolyomaviruses and primary central nervous system lymphomas
Publication TypeJournal Article
Year of Publication2004
AuthorsMurray, J, Morgello, S
JournalNeurology
Volume63
Issue7
Pagination1299-301
Date Published10/2004
Keywords80 and over, Aged, Antigens, Central Nervous System Neoplasms, Internal, Lymphoma, Non-Hodgkin, Polyomavirus, Tumor, Tumor Suppressor Protein p53, Viral
Abstract

The authors investigated the potential association of human primary CNS non-Hodgkin lymphoma (PCNSL) with polyomavirus in HIV-1 infected and uninfected individuals. Immunohistochemical analysis of CNS biopsies from 19 HIV-negative and 17 HIV-positive patients and PCR analysis of 12 HIV-negative and 14 HIV-positive patients revealed that the lymphomas were uniformly negative for polyomaviruses. The authors conclude that polyomaviruses are unlikely to be related to the pathogenesis of most PCNSL.
URLhttp://www.ncbi.nlm.nih.gov/pubmed/15477558