Optimizing measures of HIV-associated neuropathy.
| Title | Optimizing measures of HIV-associated neuropathy. |
| Publication Type | Journal Article |
| Year of Publication | 2015 |
| Authors | Robinson-Papp, JS, Sharma, S, Dhadwal, N, Simpson, DM, Morgello, S |
| Journal | Muscle Nerve |
| Volume | 51 |
| Issue | 1 |
| Pagination | 56-64 |
| Date Published | 2015 Jan |
| ISSN | 1097-4598 |
| Keywords | Adult, AIDS-Associated Nephropathy, Female, Humans, Internal, Male, Middle Aged, Neural Conduction, Neurologic Examination, Pain, Peripheral Nerves, Severity of Illness Index |
| Abstract | INTRODUCTION: Distal symmetric polyneuropathy (DSP) is common in HIV and is associated with autonomic impairment. However tools to measure HIV-DSP do not include autonomic indices. We sought to optimize the Total Neuropathy Score (TNS) and the Composite Autonomic Severity Score (CASS) for use in HIV.METHODS: HIV-infected adults (n = 102) underwent neurologic examination, quantitative sensory testing (QST), nerve conduction studies, and autonomic testing. Modifications of the TNS and CASS were assessed for validity based on correlation with the original measure and internal consistency.RESULTS: The TNS version commonly used in HIV-DSP is valid, but it is improved by elimination of QST and addition of autonomic indices. A modified version of the CASS (M-CASS) which was designed for sensitivity to milder impairment was also valid.CONCLUSIONS: A modified TNS that excludes QST and includes autonomic indices is optimal for HIV-DSP. The M-CASS is a valid measure of autonomic impairment in HIV. |
| DOI | 10.1002/mus.24282 |
| Alternate Journal | Muscle Nerve |
| PubMed ID | 24809943 |
| PubMed Central ID | PMC4225193 |
| Grant List | K23 NS066789 / NS / NINDS NIH HHS / United States K23 NS066789 / NS / NINDS NIH HHS / United States L60 MD002855 / MD / NIMHD NIH HHS / United States |
