No detection of CD4-independent human immunodeficiency virus 1 envelope glycoproteins in brain tissue of patients with or without neurological complications.
Title | No detection of CD4-independent human immunodeficiency virus 1 envelope glycoproteins in brain tissue of patients with or without neurological complications. |
Publication Type | Journal Article |
Year of Publication | 2019 |
Authors | Quitadamo, B, Peters, PJ, Koch, M, Luzuriaga, K, Cheng-Mayer, C, Clapham, PR, Gonzalez-Perez, MPaz |
Journal | Arch Virol |
Volume | 164 |
Issue | 2 |
Pagination | 473-482 |
Date Published | 2019 Feb |
ISSN | 1432-8798 |
Keywords | Brain, CD4 Antigens, HIV Envelope Protein gp120, HIV Infections, HIV-1, Humans, Macrophages, Nervous System Diseases, Phylogeny, Receptors, CCR5, Receptors, Virus |
Abstract | Macrophage (mac)-tropic human immnunodeficiency virus type 1 (HIV-1) and simian immnunodeficiency virus (SIV) in brain are associated with neurological disease. Mac-tropic HIV-1 evolves enhanced CD4 interactions that enable macrophage infection via CD4, which is in low abundance. In contrast, mac-tropic SIV is associated with CD4-independent infection via direct CCR5 binding. Recently, mac-tropic simian-human immunodeficiency virus (SHIV) from macaque brain was also reported to infect cells via CCR5 without CD4. Since SHIV envelope proteins (Envs) are derived from HIV-1, we tested more than 100 HIV-1 clade B Envs for infection of CD4-negative, CCR5 Cf2Th/CCR5 cells. However, no infection was detected. Our data suggest that there are differences in the evolution of mac-tropism in SIV and SHIV compared to HIV-1 clade B due to enhanced interactions with CCR5 and CD4, respectively. |
DOI | 10.1007/s00705-018-4094-1 |
Alternate Journal | Arch Virol |
PubMed ID | 30415390 |
PubMed Central ID | PMC6369005 |
Grant List | U24 MH100929 / MH / NIMH NIH HHS / United States NS095749 / NS / NINDS NIH HHS / United States NS084910 / NS / NINDS NIH HHS / United States R01 NS095749 / NS / NINDS NIH HHS / United States R01 NS107022 / NS / NINDS NIH HHS / United States U24 MH100928 / MH / NIMH NIH HHS / United States NS107022 / NS / NINDS NIH HHS / United States |