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Molecular and clinical assessment in the treatment of AIDS Kaposi sarcoma with valproic Acid

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TitleMolecular and clinical assessment in the treatment of AIDS Kaposi sarcoma with valproic Acid
Publication TypeJournal Article
Year of Publication2009
AuthorsLechowicz, M, Dittmer, DP, Lee, JY, Krown, SE, Wachsman, W, Aboulafia, D, Dezube, BJ, Ratner, L, Said, JW, Ambinder, RF
JournalClinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Volume49
Issue12
Pagination1946-1949
Date Published12/2009
KeywordsAcquired Immunodeficiency Syndrome, Adult, External, Female, Herpesvirus 8, Human, Humans, Kaposi, Male, Middle Aged, Prospective Studies, RNA, Sarcoma, Valproic Acid, Viral
Abstract

The AIDS Malignancy Consortium undertook a pilot trial of valproic acid among patients with AIDS-associated Kaposi sarcoma (KS). Treatment was associated with low toxicity, but the KS clinical response and KS herpesvirus lytic induction rates were not sufficiently high to meet predefined criteria for efficacy.
URLhttp://www.ncbi.nlm.nih.gov/pubmed/19911999
DOI10.1086/648447