Identification of Youthful Neurocognitive Trajectories in Adults Aging with HIV: A Latent Growth Mixture Model.
Title | Identification of Youthful Neurocognitive Trajectories in Adults Aging with HIV: A Latent Growth Mixture Model. |
Publication Type | Journal Article |
Year of Publication | 2022 |
Authors | Saloner, R, Lobo, JD, Paolillo, EW, Campbell, LM, Letendre, SL, Cherner, M, Grant, I, Heaton, RK, Ellis, RJ, Roesch, SC, Moore, DJ |
Corporate Authors | CHARTER Study Group |
Journal | AIDS Behav |
Volume | 26 |
Issue | 6 |
Pagination | 1966-1979 |
Date Published | 2022 Jun |
ISSN | 1573-3254 |
Keywords | CHARTER, Internal |
Abstract | Despite the neurocognitive risks of aging with HIV, initial cross-sectional data suggest a subpopulation of older people with HIV (PWH) possess youthful neurocognition (NC) characteristic of SuperAgers (SA). Here we characterize longitudinal NC trajectories of older PWH and their convergent validity with baseline SA status, per established SuperAging criteria in PWH, and baseline biopsychosocial factors. Growth mixture modeling (GMM) identified longitudinal NC classes in 184 older (age ≥ 50-years) PWH with 1-5 years of follow-up. Classes were defined using 'peak-age' global T-scores, which compare performance to a normative sample of 25-year-olds. 3-classes were identified: Class 1 (n = 31 [16.8%], high baseline peak-age T-scores with flat trajectory); Class 2 (n = 100 [54.3%], intermediate baseline peak-age T-scores with u-shaped trajectory); Class 3 (n = 53 [28.8%], low baseline peak-age T-scores with u-shaped trajectory). Baseline predictors of Class 1 included SA status, younger age, higher cognitive and physiologic reserve, and fewer subjective cognitive difficulties. This GMM analysis supports the construct validity of SuperAging in older PWH through identification of a subgroup with longitudinally-stable, youthful neurocognition and robust biopsychosocial health. |
DOI | 10.1007/s10461-021-03546-9 |
Alternate Journal | AIDS Behav |
PubMed ID | 34878634 |
PubMed Central ID | PMC9046348 |
Grant List | F31AG064989 / AG / NIA NIH HHS / United States F31 AA027198 / AA / NIAAA NIH HHS / United States K24 DA040550 / DA / NIDA NIH HHS / United States F31AA027198 / AA / NIAAA NIH HHS / United States HHSN271201000036C / NH / NIH HHS / United States HHSN271201000036C / MH / NIMH NIH HHS / United States T32 DA031098 / DA / NIDA NIH HHS / United States N01MH2205 / MH / NIMH NIH HHS / United States N01MH22005 / MH / NIMH NIH HHS / United States P30 MH062512 / MH / NIMH NIH HHS / United States F31AG067869 / AG / NIA NIH HHS / United States R01 MH107345 / MH / NIMH NIH HHS / United States R01MH107345 / MH / NIMH NIH HHS / United States T32DA031098 / DA / NIDA NIH HHS / United States F31 AG064989 / AG / NIA NIH HHS / United States F31 AG067869 / AG / NIA NIH HHS / United States |