Harnessing regulatory T cell neuroprotective activities for treatment of neurodegenerative disorders.
Title | Harnessing regulatory T cell neuroprotective activities for treatment of neurodegenerative disorders. |
Publication Type | Journal Article |
Year of Publication | 2020 |
Authors | Machhi, J, Kevadiya, BD, Muhammad, IKhan, Herskovitz, J, Olson, KE, R Mosley, L, Gendelman, HE |
Journal | Mol Neurodegener |
Volume | 15 |
Issue | 1 |
Pagination | 32 |
Date Published | 2020 Jun 05 |
ISSN | 1750-1326 |
Keywords | External |
Abstract | Emerging evidence demonstrates that adaptive immunity influences the pathobiology of neurodegenerative disorders. Misfolded aggregated self-proteins can break immune tolerance leading to the induction of autoreactive effector T cells (Teffs) with associated decreases in anti-inflammatory neuroprotective regulatory T cells (Tregs). An imbalance between Teffs and Tregs leads to microglial activation, inflammation and neuronal injury. The cascade of such a disordered immunity includes the drainage of the aggregated protein antigens into cervical lymph nodes serving to amplify effector immune responses. Both preclinical and clinical studies demonstrate transformation of this altered immunity for therapeutic gain. We posit that the signs and symptoms of common neurodegenerative disorders such as Alzheimer's and Parkinson's diseases, amyotrophic lateral sclerosis, and stroke can be attenuated by boosting Treg activities. |
DOI | 10.1186/s13024-020-00375-7 |
Alternate Journal | Mol Neurodegener |
PubMed ID | 32503641 |
PubMed Central ID | PMC7275301 |
Grant List | P30 MH062261 / MH / NIMH NIH HHS / United States R01 AG043540 / AG / NIA NIH HHS / United States R01 NS034239 / NS / NINDS NIH HHS / United States R01 MH115860 / MH / NIMH NIH HHS / United States P01 DA028555 / DA / NIDA NIH HHS / United States |