Dementia and the Neurovirulence of HIV-1
Submitted by dcc on Wed, 04/23/2014 - 7:47am
| Title | Dementia and the Neurovirulence of HIV-1 |
| Publication Type | Journal Article |
| Year of Publication | 2000 |
| Authors | Shapshak, P, Fujimura, RK, Srivastava, A, Goodkin, K |
| Journal | CNS Spectrums |
| Volume | 5 |
| Issue | 4 |
| Pagination | 31-42 |
| Date Published | 04/2000 |
| Keywords | External |
| Abstract | Infection with human immunodeficiency virus type 1 (HIV-1) leads rapidly to infection of the brain and subsequent neuropsychological impairment, including subclinical impairment, minor cognitive-motor disorder, and HIV-1-associated dementia (HAD). This article reviews HAD and the factors involved in its pathogenesis; the effectiveness of antiretroviral therapy; the prevalence of HIV-1 and subtypes; and the role of chemokines and cytokines as the capstones associated with neuropathology due to inflammation. |
| URL | http://www.ncbi.nlm.nih.gov/pubmed?term=Dementia%20and%20the%20Neurovirulence%20of%20HIV-1%2C%20CNS%20Spectrums |
