CSF markers of AD-related pathology relate specifically to memory impairment in older people with HIV: a pilot study.
Title | CSF markers of AD-related pathology relate specifically to memory impairment in older people with HIV: a pilot study. |
Publication Type | Journal Article |
Year of Publication | 2022 |
Authors | Lobo, JD, Moore, DJ, Bondi, MW, Soontornniyomkij, V, Soontornniyomkij, B, Gouaux, B, Achim, CL, Ellis, RJ, Sundermann, EE |
Journal | J Neurovirol |
Volume | 28 |
Issue | 1 |
Pagination | 162-167 |
Date Published | 2022 Feb |
ISSN | 1538-2443 |
Keywords | CHARTER, Internal |
Abstract | Given the co-occurrence of memory impairment in HIV-associated neurocognitive disorders (HAND) and amnestic mild cognitive impairment/Alzheimer's disease (aMCI/AD), biomarkers are needed that can disentangle these conditions among people with HIV (PWH). We assessed whether cerebrospinal fluid (CSF) markers of AD could help in this effort by determining their relationship to learning and memory deficits versus cognitive deficits more characteristic of HAND than aMCI/AD (processing speed and complex visual/motor coordination) among 31 older PWH. CSF amyloid-β phosphorylated-tau, amyloid-β/amyloid-β and phosphorylated-tau/amyloid-β ratio related to learning/memory performance but not HAND-related deficits, suggesting that these biomarkers may have utility in disentangling aMCI/AD from HAND. |
DOI | 10.1007/s13365-021-01048-x |
Alternate Journal | J Neurovirol |
PubMed ID | 35103880 |
PubMed Central ID | PMC9081235 |
Grant List | R25 MH108389 / MH / NIMH NIH HHS / United States HHSN271201000030C / MH / NIMH NIH HHS / United States R01 AG049810 / AG / NIA NIH HHS / United States U24 MH100928 / MH / NIMH NIH HHS / United States T32 DA031098 / DA / NIDA NIH HHS / United States RF1 AG061070 / AG / NIA NIH HHS / United States P30 MH062512 / MH / NIMH NIH HHS / United States N01 MH022005 / MH / NIMH NIH HHS / United States R25 MH081482 / MH / NIMH NIH HHS / United States HHSN271201000036C / MH / NIMH NIH HHS / United States |