Biotypes of Central Nervous System Complications in People With Human Immunodeficiency Virus: Virology, Immunology, and Neuropathology.
Title | Biotypes of Central Nervous System Complications in People With Human Immunodeficiency Virus: Virology, Immunology, and Neuropathology. |
Publication Type | Journal Article |
Year of Publication | 2023 |
Authors | Joseph, SB, Gianella, S, Burdo, TH, Cinque, P, Gisslén, M, Letendre, S, Nath, A, Morgello, S, Ndhlovu, LC, Spudich, S |
Journal | J Infect Dis |
Volume | 227 |
Issue | Suppl 1 |
Pagination | S3-S15 |
Date Published | 2023 Mar 17 |
ISSN | 1537-6613 |
Keywords | Central Nervous System, Central Nervous System Diseases, Cognitive Dysfunction, HIV Infections, HIV-1, Humans |
Abstract | Despite viral suppression with antiretroviral therapy (ART), people with human immunodeficiency virus (HIV) continue to experience central nervous system (CNS) complications, primarily in the form of mild cognitive impairment and mental health disorders (eg, depression, anxiety, other neuropsychiatric problems). The multifactorial pathogenesis and heterogeneity of mechanisms likely underlying CNS complications must be addressed in the development of preventive interventions and effective treatments. The biotyping approach has previously been useful to define phenotypes of other CNS diseases based on underlying mechanisms and could be translated to the field of neuroHIV. The purpose of the Biotype Workshop series, and the Virology, Immunology and Neuropathology Working Group in particular, is to capitalize on current and new technologies and guide future research efforts using the wealth of available immunological, virologic, and neuropathological data collected from people with HIV on and off ART. |
DOI | 10.1093/infdis/jiac370 |
Alternate Journal | J Infect Dis |
PubMed ID | 36930640 |
PubMed Central ID | PMC10022721 |
Grant List | R25 MH108389 / MH / NIMH NIH HHS / United States R01 MH125737 / MH / NIMH NIH HHS / United States R01 AG063846 / AG / NIA NIH HHS / United States R01 MH118990 / MH / NIMH NIH HHS / United States R01 NS117458 / NS / NINDS NIH HHS / United States UM1 AI164567 / AI / NIAID NIH HHS / United States P30 MH062512 / MH / NIMH NIH HHS / United States T32 AI007384 / AI / NIAID NIH HHS / United States R01 DA050491 / DA / NIDA NIH HHS / United States R01 MH125720 / MH / NIMH NIH HHS / United States R01 AI147849 / AI / NIAID NIH HHS / United States R01 DA047879 / DA / NIDA NIH HHS / United States UM1 AI126619 / AI / NIAID NIH HHS / United States R01 DA051890 / DA / NIDA NIH HHS / United States R21 MH122243 / MH / NIMH NIH HHS / United States P30 AI036214 / AI / NIAID NIH HHS / United States R01 AG063659 / AG / NIA NIH HHS / United States R01 MH125396 / MH / NIMH NIH HHS / United States R01 MH106466 / MH / NIMH NIH HHS / United States U01 DA053625 / DA / NIDA NIH HHS / United States U24 MH100931 / MH / NIMH NIH HHS / United States UM1 AI164559 / AI / NIAID NIH HHS / United States UM1 DA051410 / DA / NIDA NIH HHS / United States R24 MH129166 / MH / NIMH NIH HHS / United States |