Axonal damage is a late component of vacuolar myelopathy
Submitted by dcc on Wed, 04/23/2014 - 7:47am
Title | Axonal damage is a late component of vacuolar myelopathy |
Publication Type | Journal Article |
Year of Publication | 2002 |
Authors | Rottnek, M, DiRocco, A, Laudier, D, Morgello, S |
Journal | Neurology |
Volume | 58 |
Issue | 3 |
Pagination | 479-81 |
Date Published | 02/2002 |
Keywords | 80 and over, Aged, Amyloid beta-Protein Precursor, Antigens, CD, Differentiation, Internal, Myelomonocytic, Spinal Cord Diseases |
Abstract | The role of axonopathy in myelin disorders recently has been examined. To investigate axonal pathologic changes in vacuolar myelopathy (VM), semiquantitative immunohistochemical stains for inflammation, axonal damage, and gliosis were performed on spinal cord sections from patients with AIDS with and without VM and from HIV-negative controls. Significant axonal damage was present in only moderate to severe VM, despite inflammation at all stages. The authors conclude that axonal damage is not present in early disease; it is present in moderate to severe vacuolar myelopathy and may contribute to clinical deficits in late stages of this disorder. |
URL | http://www.ncbi.nlm.nih.gov/pubmed/11839857 |