Antiretroviral Penetration across Three Preclinical Animal Models and Humans in Eight Putative HIV Viral Reservoirs.
Submitted by dcc on Fri, 01/08/2021 - 3:18pm
| Title | Antiretroviral Penetration across Three Preclinical Animal Models and Humans in Eight Putative HIV Viral Reservoirs. |
| Publication Type | Journal Article |
| Year of Publication | 2019 |
| Authors | Devanathan, AS, Pirone, JR, Akkina, R, Remling-Mulder, L, Luciw, P, Adamson, L, J Garcia, V, Kovarova, M, White, NR, Schauer, AP, Blake, K, Sykes, C, Burgunder, EM, Srinivas, N, Rosen, EP, Kashuba, ADM |
| Journal | Antimicrob Agents Chemother |
| Volume | 64 |
| Issue | 1 |
| Date Published | 2019 12 20 |
| ISSN | 1098-6596 |
| Keywords | Animals, Anti-HIV Agents, Anti-Retroviral Agents, Atazanavir Sulfate, Emtricitabine, Female, HIV Infections, Humans, In Vitro Techniques, Maraviroc, Mice, Raltegravir Potassium, Tenofovir |
| Abstract | For HIV cure strategies like "kick and kill" to succeed, antiretroviral (ARV) drugs must reach effective concentrations in putative viral reservoirs. We characterize penetration of six ARVs in three preclinical animal models and humans. We found that standard dosing strategies in preclinical species closely mimicked tissue concentrations in humans for some, but not all, ARVs. These results have implications for interpreting HIV treatment, prevention, or cure interventions between preclinical and clinical models. |
| DOI | 10.1128/AAC.01639-19 |
| Alternate Journal | Antimicrob Agents Chemother |
| PubMed ID | 31611355 |
| PubMed Central ID | PMC7187610 |
| Grant List | U24 MH100929 / MH / NIMH NIH HHS / United States U24 MH100931 / MH / NIMH NIH HHS / United States U24 MH100928 / MH / NIMH NIH HHS / United States P51 OD011107 / OD / NIH HHS / United States R01 AI111891 / AI / NIAID NIH HHS / United States T32 GM086330 / GM / NIGMS NIH HHS / United States U24 MH100930 / MH / NIMH NIH HHS / United States U01 AI095031 / AI / NIAID NIH HHS / United States P30 AI050410 / AI / NIAID NIH HHS / United States |
