Date Published:
10/2004

Publication Type:
Journal Article

Authors:

J. Murray
S. Morgello

Secondary:
Neurology

Volume:
63

Pagination:
1299-301

Issue:
7

URL:
https://pubmed.ncbi.nlm.nih.gov/

Keywords:
80 and over;Aged;Antigens;Central Nervous System Neoplasms;Internal;Lymphoma;Non-Hodgkin;Polyomavirus;Tumor;Tumor Suppressor Protein p53;Viral

Abstract:
<p>The authors investigated the potential association of human primary CNS non-Hodgkin lymphoma (PCNSL) with polyomavirus in HIV-1 infected and uninfected individuals. Immunohistochemical analysis of CNS biopsies from 19 HIV-negative and 17 HIV-positive patients and PCR analysis of 12 HIV-negative and 14 HIV-positive patients revealed that the lymphomas were uniformly negative for polyomaviruses. The authors conclude that polyomaviruses are unlikely to be related to the pathogenesis of most PCNSL.</p>