Date Published:
12/2004
Publication Type:
Journal Article
Authors:
Secondary:
Journal of Neuroimmunology
Volume:
157
Pagination:
185-92
Issue:
1-2
URL:
https://pubmed.ncbi.nlm.nih.gov/
Keywords:
CCR2;CCR5;Chemokine;Genetic;Internal;Polymorphism;Receptors
Abstract:
<p>CCR2 is a minor coreceptor for human immune deficiency virus-1 (HIV-1) and its impact on HIV-1-related neuropsychological impairment (NPI) remains unknown. We studied the impact of CCR2-V64I polymorphisms on the development of NPI in 121 HIV-1 patients. The CCR2-64-I allele was associated with rate of progression to NPI when measured from the first study visit (Log Rank p=0.01) or from the estimated time of seroconversion (p=0.02). CCR2-V64I was not associated with plasma or CSF HIV-1 RNA load, suggesting that the impact of CCR2 on neuropathogenesis may involve alterations in inflammatory responses within the CNS rather than a direct impact on viral entry or replication.</p>