Date Published:
2006

Publication Type:
Journal Article

Authors:

S. Monteiro de Almeida
S. Letendre
J. Zimmerman
S. Kolakowski
D. Lazzaretto
J.A. McCutchan
R.J. Ellis

Secondary:
Journal of Neuroimmunology

Volume:
179

Pagination:
180-5

URL:
https://pubmed.ncbi.nlm.nih.gov/

Keywords:
Adult;Anti-Retroviral Agents;Cerebrospinal Fluid;Chemokine CCL2;Chemotaxis;Drug Administration Schedule;HIV Infections;Humans;Internal;Leukocyte;Leukocytosis;Male;Middle Aged

Abstract:
<p>Although monocyte chemoattractant protein (MCP-1)/CCL2 is believed to mediate trafficking of HIV-activated leukocytes into the CNS, its role has not been studied directly in humans. To evaluate MCP-1's effects on CNS leukocyte infiltration, we measured CSF leukocytes and MCP-1 levels in serial plasma and cerebrospinal fluid (CSF) samples from subjects who experienced large increases in viral load after interrupting antiretrovirals. Following large increases in CSF MCP-1, CSF leukocytosis (15-166 cells/microL) developed in 4 of 6 subjects. Both initial MCP-1 levels and subsequent changes were 3-fold larger in CSF than plasma. The magnitude and timing of changes suggested that MCP-1 triggers the development of CSF pleocytosis.</p>