Home /Diminished somatostatin gene expression in individuals with HIV and major depressive disorder

Diminished somatostatin gene expression in individuals with HIV and major depressive disorder

Submitted by dcc on Wed, 04/23/2014 - 7:47am
TitleDiminished somatostatin gene expression in individuals with HIV and major depressive disorder
Publication TypeJournal Article
Year of Publication2006
AuthorsEverall, I, Salaria, S, Atkinson, JH, Young, C, Corbeil, J, Grant, I, Masliah, E
JournalNeurology
Volume67
Pagination1867-9
Date Published2006
KeywordsAdult, AIDS Dementia Complex, Brain, Cytoskeletal Proteins, Depressive Disorder, Down-Regulation, Gene Expression Regulation, Genetic Markers, Humans, Internal, Major, Male, Middle Aged, Nerve Degeneration, Neurons, Somatostatin
Abstract

In analyzing the expression of 15 candidate genes for HIV encephalitis (HIVE) by the presence or absence of major depressive disorder (MDD), we noted significant reductions in the expression of four cytoskeletal genes and somatostatin. Whereas disruption of cytoskeletal genes has been noted in HIVE, dysregulation of somatostatin has not, indicating that dysregulation of somatostatin is part of the molecular pathologic process of MDD in the setting of HIV.
URLhttp://www.ncbi.nlm.nih.gov/pubmed/17130427