Cognitive deficits and degeneration of interneurons in HIV+ methamphetamine users

TitleCognitive deficits and degeneration of interneurons in HIV+ methamphetamine users
Publication TypeJournal Article
Year of Publication2006
AuthorsChana, G, Everall, I, Crews, LA, Langford, D, Adame, A, Grant, I, Cherner, M, Lazzaretto, D, Heaton, RK, Ellis, RJ, Masliah, E
JournalNeurology
Volume67
Issue8
Pagination1486-9
Date Published10/2006
KeywordsAmphetamine-Related Disorders, Cadaver, Cognition Disorders, Frontal Lobe, HIV Seropositivity, Humans, Internal, Interneurons, Memory Disorders, Methamphetamine, Nerve Degeneration, Severity of Illness Index
Abstract

The cellular basis for cognitive deficits in HIV+ patients with and without a history of methamphetamine (METH) use is unclear. We found that HIV+ METH users had more severe loss of interneurons that was associated with cognitive impairment. Compared with other markers, loss of calbindin and parvalbumin interneurons in the frontal cortex was the most significant correlate to memory deficits, suggesting a role in neurobehavioral alterations of HIV+ METH users.

URLhttp://www.ncbi.nlm.nih.gov/pubmed/17060582