Chronically elevated depressive symptoms interact with acute increases in inflammation to predict worse neurocognition among people with HIV.
Submitted by dcc on Fri, 05/14/2021 - 11:20am
Title | Chronically elevated depressive symptoms interact with acute increases in inflammation to predict worse neurocognition among people with HIV. |
Publication Type | Journal Article |
Year of Publication | 2021 |
Authors | Saloner, R, Paolillo, EW, Heaton, RK, Grelotti, DJ, Stein, MB, Miller, AH, J Atkinson, H, Letendre, SL, Ellis, RJ, Grant, I, Iudicello, JE, Moore, DJ |
Journal | J Neurovirol |
Volume | 27 |
Issue | 1 |
Pagination | 160-167 |
Date Published | 2021 Feb |
ISSN | 1538-2443 |
Keywords | CHARTER, Internal |
Abstract | We examined the joint effects of depressive symptoms (Beck Depression Inventory-II (BDI-II)) and systemic inflammation (plasma C-reactive protein (CRP)) on longitudinal profiles of neurocognition in a cohort of 143 people with HIV (PWH) on antiretroviral therapy. Global neurocognition, processing speed, motor skills, and attention/working memory all worsened as CRP increased but only among PWH who, on average, exhibited moderate to severe depressive symptoms (BDI-II > 22). Findings suggest that some PWH with chronically elevated depressive symptoms may have an inflammatory subtype of depression and a particular vulnerability to neurocognitive changes that may respond to drugs targeting inflammation or its neural sequelae. |
DOI | 10.1007/s13365-020-00925-1 |
Alternate Journal | J Neurovirol |
PubMed ID | 33405198 |
Grant List | F31AG064989 / AG / NIA NIH HHS / United States F31 AA027198 / AA / NIAAA NIH HHS / United States F31AA027198 / AA / NIAAA NIH HHS / United States HHSN271201000036C / NH / NIH HHS / United States HHSN271201000030C / NH / NIH HHS / United States P30 MH062512 / MH / NIMH NIH HHS / United States F31 AG064989 / AG / NIA NIH HHS / United States P30MH062512 / MH / NIMH NIH HHS / United States P30MH062512 / MH / NIMH NIH HHS / United States HHSN271201000036C / NH / NIH HHS / United States HHSN271201000030C / NH / NIH HHS / United States F31AG064989 / AG / NIA NIH HHS / United States F31AA027198 / AA / NIAAA NIH HHS / United States |