Chemokine receptors and neurotrophic factors: potential therapy against aids dementia?

TitleChemokine receptors and neurotrophic factors: potential therapy against aids dementia?
Publication TypeJournal Article
Year of Publication2008
AuthorsMocchetti, I, Bachis, A, Masliah, E
JournalJournal of Neuroscience Research
Volume86
Pagination243-55
Date Published2008
KeywordsChemokine, Internal, Nerve Growth Factors, Receptors
Abstract

Chemokine receptors, in particular, CXCR4 and CCR5, mediate human immunodeficiency virus type 1 (HIV-1) infection of immunocompetent cells and the apoptosis of these cells. However, the virus does not infect neurons. Yet through a variety of mechanisms, HIV promotes glial cell activation, synaptodendritic alterations, and neuronal loss that ultimately lead to motor and cognitive impairment. Chemokines and chemokine receptors are abundant in the adult central nervous system and play a role in neuronal apoptosis evoked by HIV proteins. Thus, reducing the availability of chemokine receptors may prevent the neuronal degeneration seen in HIV-positive patients. In this article, we present and discuss a recent experimental approach aimed at testing effective neuroprotective therapies against HIV-mediated neuronal degeneration.

URLhttp://www.ncbi.nlm.nih.gov/pubmed/17847079